2nd August 2012
Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Our paper in 2007 (reference below) suggested that Immunoglobulin given intravenously to mice could protect the brain against experimental stroke by preventing complement-mediated neuronal cell death. That study is now being translated into human volunteers in a clinical trial starting this week.
Arumugam, T.V.; Tang, S.-C.; Lathia, J. D.; Cheng, A.; Mughal, M. R.;Chigurupati,S.; Magnus, T.; Chan, S.L.; Jo, D-G.; Ouyang, X.; Fairlie, D.P.; Granger, D. N.; Vortmeyer, A.; Basta, M.; Mattson, M.P. Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc. Natl. Acad. Sci. (USA) 2007, 104, 14104-14109.
Fairlie Group Home Page: http://fairlie.imb.uq.edu.au