New drug lead shows promise as potential treatment for obesity

23 August 2013

Scientists from The University of Queensland have discovered a new drug lead that prevents rats on a high-fat, high-sugar diet from becoming obese.

Professor David Fairlie, from UQ’s Institute for Molecular Bioscience, led the study, which provides strong evidence that drugs designed to treat inflammatory diseases may also be able to prevent and treat obesity.

“Obesity and diabetes have reached epidemic proportions in both adults and children,” Professor Fairlie said.

“The clear need for new treatments, combined with the hypothesis that obesity is actually an inflammatory disease, prompted us to study one of our anti-inflammatory compounds for its capacity to prevent and treat obesity in rats.”


New C3a Paper published

Efficient chemical synthesis of human complement protein C3a

Artin Ghassemian,zy Ching-I Anderson Wang,y Mei-Kwan Yau, Robert C. Reid, Richard J. Lewis, David P. Fairlie, Paul F. Alewood and Thomas Durek

Chem Commun, 2013, 49, 2356-2358.

Fairlie Group Home Page:


Nature Communication Published

Patel O, Kjer-Nielsen L, Nours JL, Eckle SBG, Bikinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Mehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J.

Nature Commun 2013, doi: 10.1038/ncomms3142.

Fairlie Group Home Page: