Drugs and Drug-Like Molecules Activate or Inhibit T cells

7 February, 2017

PhD student Weijun Xu from The University of Queensland’s Institute for Molecular Bioscience used computer modelling to predict chemical structures, drugs and drug-like molecules that activate or inhibit T cells called MAIT cells. Such small compounds included salicylates, non-steroidal anti-inflammatory drugs like diclofenac, and drug metabolites. Researchers from University of Queensland, Monash University and University of Melbourne are a step closer to understanding immune sensitivities to well-known, and commonly prescribed, medications (Nature Immunology 2017, doi: 10.1038/ni.3679 [Epub ahead of print]).