The Fairlie group works at the interface of chemistry, biology and disease. We apply our skills in medicinal chemistry, biochemistry and pharmacology to develop new treatments for cancer, inflammatory diseases, metabolic diseases (type 2 diabetes, obesity, cardiovascular), viral infections, and Alzheimer’s disease.
|Chemistry researchers in our group develop expertise in medicinal and organic chemistry using solution and solid phase organic synthesis; structure determination through 2D NMR spectroscopy; computer-aided drug design; and study interactions between small molecules and proteins, DNA and RNA. Outcomes are new chemical reactions, chemical mechanisms, organic compounds, chemical structures, enzyme inhibitors, protein agonists and antagonists, and structural mimics of protein surfaces, as new leads to drugs, diagnostics and vaccines.||Biology researchers in our group interrogate human protein and cell function, and elucidate mechanisms of protein activation, biological/physiological processes, disease development, and drug action. Some researchers study rat or mouse models of human diseases. Researchers gain insights to human physiology or aberrant processes in disease, and develop interdisciplinary skills in enzymology, biochemistry, pharmacology, immunology, virology, parasitology, oncology and neurobiology.|
Our research on diseases involves basic, strategic and applied research in biochemistry and pharmacology directed at: (1) understanding how the immune system resolves infection (by parasites, viruses, bacteria) and tissue injury; (2) how prolonged inflammatory responses can cause debilitating chronic inflammatory diseases, including onset of cancers, metabolic diseases (obesity, type 2 diabetes, atherosclerosis, cardiovascular diseases), chronic inflammatory pain, and neurodegenerative diseases (e.g. Alzheimer’s disease); and (3) how our novel compounds can act on human proteins, human and rodent cells and tissues, and rat or mouse models of human diseases. See links for our publications in all of these disease areas and allied chemical, biochemical and pharmacological research.